Drug interactions
Ertugliflozin + Lithium
Severity: Moderate
Ertugliflozin and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SGLT2 inhibitors may lower serum lithium concentrations. A fall in lithium levels can lead to loss of mood stabilization and relapse in patients who were previously well controlled.
What this interaction means in plain words
Ertugliflozin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
Probably increased renal lithium clearance related to SGLT2 inhibition and its effects on sodium and volume handling; the mechanism is not fully established.
What to do
Measure serum lithium more often when ertugliflozin is started, stopped or its dose changed. Adjust the lithium dose according to levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Ertugliflozin
- Chlorpropamide + Ertugliflozin Moderate
- Ertugliflozin + Glibenclamide Moderate
- Ertugliflozin + Gliclazide Moderate
- Ertugliflozin + Glimepiride Moderate
- Ertugliflozin + Glimepiride-pioglitazone Moderate
- Ertugliflozin + Glipizide Moderate
Frequently asked questions
Can I take Ertugliflozin with Lithium?
MediHelp rates the interaction as moderate. Ertugliflozin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors may lower serum lithium concentrations. A fall in lithium levels can lead to loss of mood stabilization and relapse in patients who were previously well controlled.
How serious is the interaction between Ertugliflozin and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum lithium more often when ertugliflozin is started, stopped or its dose changed. Adjust the lithium dose according to levels and clinical response.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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