Drug interactions
Ertugliflozin-sitagliptin + Ethanol
Severity: Moderate
Ertugliflozin-sitagliptin and Ethanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heavy alcohol intake disturbs glucose control, causing hypoglycemia or hyperglycemia, and raises the risk of pancreatitis, a recognized concern with sitagliptin. Alcohol also increases the risk of ketoacidosis and volume depletion with SGLT2 inhibitors like ertugliflozin.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alcohol alters hepatic gluconeogenesis and insulin response, and adds to ketoacidosis, dehydration and pancreatitis risks of the drug components.
What to do
Advise patients to avoid excessive or binge drinking and to keep intake modest with food. Counsel on symptoms of ketoacidosis, dehydration and pancreatitis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Ethanol?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heavy alcohol intake disturbs glucose control, causing hypoglycemia or hyperglycemia, and raises the risk of pancreatitis, a recognized concern with sitagliptin. Alcohol also increases the risk of ketoacidosis and volume depletion with SGLT2 inhibitors like ertugliflozin.
How serious is the interaction between Ertugliflozin-sitagliptin and Ethanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid excessive or binge drinking and to keep intake modest with food. Counsel on symptoms of ketoacidosis, dehydration and pancreatitis.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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