Drug interactions
Ertugliflozin-sitagliptin + Glibenclamide
Severity: Moderate
Ertugliflozin-sitagliptin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding ertugliflozin and sitagliptin to glyburide increases hypoglycemia risk. Glyburide has active metabolites that accumulate in renal impairment, adding to the risk.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Glibenclamide belongs to Endocrine.
Why it happens
Additive glucose-lowering effects, with insulin secretion stimulated by the sulfonylurea and sitagliptin.
What to do
Consider reducing the glyburide dose when starting the combination and monitor blood glucose, especially in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Glibenclamide?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding ertugliflozin and sitagliptin to glyburide increases hypoglycemia risk. Glyburide has active metabolites that accumulate in renal impairment, adding to the risk.
How serious is the interaction between Ertugliflozin-sitagliptin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting the combination and monitor blood glucose, especially in renal impairment.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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