Drug interactions
Ertugliflozin-sitagliptin + Indinavir
Severity: Moderate
Ertugliflozin-sitagliptin and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is associated with insulin resistance and hyperglycemia, which may reduce the efficacy of antidiabetic drugs. Indinavir has been linked to impaired glucose tolerance more than some other protease inhibitors.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitor-induced insulin resistance, partly through reduced GLUT4-mediated glucose uptake.
What to do
Monitor blood glucose and HbA1c after starting indinavir and adjust antidiabetic therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ertugliflozin-sitagliptin and Indinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ertugliflozin-sitagliptin
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Indinavir?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is associated with insulin resistance and hyperglycemia, which may reduce the efficacy of antidiabetic drugs. Indinavir has been linked to impaired glucose tolerance more than some other protease inhibitors.
How serious is the interaction between Ertugliflozin-sitagliptin and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting indinavir and adjust antidiabetic therapy as required.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
