Drug interactions
Ertugliflozin-sitagliptin + Insulin aspart protamine / insulin aspart
Severity: Moderate
Ertugliflozin-sitagliptin and Insulin aspart protamine / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding ertugliflozin and sitagliptin to insulin adds glucose-lowering effects and raises the risk of hypoglycemia. The risk is greater when insulin doses are not reduced as these agents are started.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering from insulin, SGLT2 inhibition and DPP-4 inhibition.
What to do
Consider lowering the insulin dose when starting ertugliflozin-sitagliptin and monitor blood glucose closely. Educate patients on hypoglycemia recognition and treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ertugliflozin-sitagliptin and Insulin aspart protamine / insulin aspart, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ertugliflozin-sitagliptin
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Insulin aspart protamine / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding ertugliflozin and sitagliptin to insulin adds glucose-lowering effects and raises the risk of hypoglycemia. The risk is greater when insulin doses are not reduced as these agents are started.
How serious is the interaction between Ertugliflozin-sitagliptin and Insulin aspart protamine / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting ertugliflozin-sitagliptin and monitor blood glucose closely. Educate patients on hypoglycemia recognition and treatment.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
