Drug interactions
Ertugliflozin-sitagliptin + Insulin aspart
Severity: Moderate
Ertugliflozin-sitagliptin and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding ertugliflozin-sitagliptin to insulin increases the glucose-lowering effect and the risk of hypoglycemia. Insulin doses often need to be lowered when starting these agents. Ertugliflozin may also increase the risk of ketoacidosis if insulin is cut too much.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Insulin aspart belongs to Endocrine.
Why it happens
Additive glucose-lowering pharmacodynamic effects through insulin action, SGLT2 inhibition and DPP-4 inhibition.
What to do
Consider reducing the insulin aspart dose when starting the combination and monitor blood glucose frequently. Avoid excessive insulin reduction and watch for ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Insulin aspart
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Insulin aspart?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding ertugliflozin-sitagliptin to insulin increases the glucose-lowering effect and the risk of hypoglycemia. Insulin doses often need to be lowered when starting these agents. Ertugliflozin may also increase the risk of ketoacidosis if insulin is cut too much.
How serious is the interaction between Ertugliflozin-sitagliptin and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin aspart dose when starting the combination and monitor blood glucose frequently. Avoid excessive insulin reduction and watch for ketoacidosis symptoms.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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