Drug interactions
Ertugliflozin-sitagliptin + Insulin lispro protamine / insulin lispro
Severity: Moderate
Ertugliflozin-sitagliptin and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ertugliflozin and sitagliptin used with premixed lispro insulin add to glucose lowering and raise hypoglycemia risk. Insulin doses commonly need reduction when these agents are added.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose lowering from insulin, SGLT2 inhibition and DPP-4 inhibition.
What to do
Consider reducing the insulin dose at initiation and monitor blood glucose closely, re-titrating as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ertugliflozin and sitagliptin used with premixed lispro insulin add to glucose lowering and raise hypoglycemia risk. Insulin doses commonly need reduction when these agents are added.
How serious is the interaction between Ertugliflozin-sitagliptin and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose at initiation and monitor blood glucose closely, re-titrating as needed.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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