Drug interactions
Ertugliflozin-sitagliptin + Insulin lispro
Severity: Moderate
Ertugliflozin-sitagliptin and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining the ertugliflozin and sitagliptin product with insulin lispro produces additive glucose lowering and raises hypoglycemia risk. Insulin dose reduction is often required.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Additive glucose-lowering effects via insulin action, SGLT2-mediated glycosuria and DPP-4 inhibition enhancing incretin activity.
What to do
Consider lowering the insulin lispro dose when starting the combination and monitor blood glucose closely. Re-titrate insulin as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Insulin lispro
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Insulin lispro?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining the ertugliflozin and sitagliptin product with insulin lispro produces additive glucose lowering and raises hypoglycemia risk. Insulin dose reduction is often required.
How serious is the interaction between Ertugliflozin-sitagliptin and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin lispro dose when starting the combination and monitor blood glucose closely. Re-titrate insulin as needed.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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