Drug interactions
Ertugliflozin-sitagliptin + Insulin regular human
Severity: Moderate
Ertugliflozin-sitagliptin and Insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding ertugliflozin and sitagliptin to insulin lowers blood glucose further, and the combined effect can cause hypoglycemia. The risk is highest when the insulin dose was set before the other agents were added.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering pharmacodynamic effects: SGLT2 inhibition and DPP-4 inhibition combined with exogenous insulin.
What to do
Consider lowering the insulin dose when starting the combination and monitor blood glucose closely. Re-adjust insulin if the combination is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Insulin regular human?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding ertugliflozin and sitagliptin to insulin lowers blood glucose further, and the combined effect can cause hypoglycemia. The risk is highest when the insulin dose was set before the other agents were added.
How serious is the interaction between Ertugliflozin-sitagliptin and Insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the insulin dose when starting the combination and monitor blood glucose closely. Re-adjust insulin if the combination is stopped.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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