Drug interactions
Ertugliflozin-sitagliptin + Lithium
Severity: Moderate
Ertugliflozin-sitagliptin and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SGLT2 inhibitors such as ertugliflozin may lower serum lithium concentrations, possibly reducing mood-stabilising efficacy. Relapse could occur if levels fall below the therapeutic range.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
Proposed alteration of renal lithium handling by SGLT2 inhibition; the exact mechanism is not firmly established.
What to do
Check serum lithium more often when starting ertugliflozin, changing its dose or stopping it. Adjust the lithium dose to keep levels in the target range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Lithium?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors such as ertugliflozin may lower serum lithium concentrations, possibly reducing mood-stabilising efficacy. Relapse could occur if levels fall below the therapeutic range.
How serious is the interaction between Ertugliflozin-sitagliptin and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum lithium more often when starting ertugliflozin, changing its dose or stopping it. Adjust the lithium dose to keep levels in the target range.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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