Drug interactions
Ertugliflozin-sitagliptin + Olanzapine
Severity: Moderate
Ertugliflozin-sitagliptin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine frequently causes weight gain, insulin resistance and hyperglycemia, which can counteract the effects of antidiabetic therapy. Glycemic control may deteriorate after it is started.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance and impaired glucose regulation.
What to do
Check fasting glucose and HbA1c at baseline and regularly during olanzapine therapy. Intensify antidiabetic treatment or consider a more metabolically neutral antipsychotic if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Olanzapine
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Olanzapine?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine frequently causes weight gain, insulin resistance and hyperglycemia, which can counteract the effects of antidiabetic therapy. Glycemic control may deteriorate after it is started.
How serious is the interaction between Ertugliflozin-sitagliptin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose and HbA1c at baseline and regularly during olanzapine therapy. Intensify antidiabetic treatment or consider a more metabolically neutral antipsychotic if control worsens.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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