Drug interactions
Ertugliflozin-sitagliptin + Tenofovir df
Severity: Minor
Ertugliflozin-sitagliptin and Tenofovir df: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs undergo renal elimination, so they could compete for tubular secretion. Tenofovir can also impair kidney function, which would increase sitagliptin exposure.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular transport, and tenofovir-related reduction in renal function can reduce sitagliptin clearance.
What to do
Monitor renal function periodically and adjust the sitagliptin dose if eGFR falls to a level requiring adjustment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ertugliflozin-sitagliptin
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Tenofovir df?
MediHelp rates the interaction as minor. Ertugliflozin-sitagliptin and Tenofovir df have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs undergo renal elimination, so they could compete for tubular secretion. Tenofovir can also impair kidney function, which would increase sitagliptin exposure.
How serious is the interaction between Ertugliflozin-sitagliptin and Tenofovir df?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function periodically and adjust the sitagliptin dose if eGFR falls to a level requiring adjustment.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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