Drug interactions
Erythromycin + Montelukast
Severity: Minor
Erythromycin and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Montelukast is metabolized partly by CYP3A4, but also by CYP2C8 and CYP2C9. Erythromycin is unlikely to meaningfully change its exposure, and montelukast has a wide safety margin.
What this interaction means in plain words
Erythromycin and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Erythromycin belongs to Anti Bacterial; Montelukast belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4-mediated montelukast metabolism by erythromycin.
What to do
No dose adjustment is needed. Watch for increased adverse effects such as headache or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Erythromycin with Montelukast?
MediHelp rates the interaction as minor. Erythromycin and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Montelukast is metabolized partly by CYP3A4, but also by CYP2C8 and CYP2C9. Erythromycin is unlikely to meaningfully change its exposure, and montelukast has a wide safety margin.
How serious is the interaction between Erythromycin and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Watch for increased adverse effects such as headache or gastrointestinal upset.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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