Drug interactions
Erythromycin + Pacritinib
Severity: Major
Erythromycin and Pacritinib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is metabolized mainly by CYP3A4, and erythromycin can raise its levels. Increased exposure may heighten the risk of QT prolongation, bleeding, diarrhea and other toxicities.
What this interaction means in plain words
Erythromycin and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin belongs to Anti Bacterial; Pacritinib belongs to Oncology.
Why it happens
Erythromycin inhibits CYP3A4, reducing pacritinib clearance.
What to do
Avoid the combination and choose a non-CYP3A4-inhibiting antibiotic. If unavoidable, monitor ECG, and for bleeding and adverse effects, with pacritinib dose reduction per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Erythromycin with Pacritinib?
MediHelp rates the interaction as major. Erythromycin and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pacritinib is metabolized mainly by CYP3A4, and erythromycin can raise its levels. Increased exposure may heighten the risk of QT prolongation, bleeding, diarrhea and other toxicities.
How serious is the interaction between Erythromycin and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-CYP3A4-inhibiting antibiotic. If unavoidable, monitor ECG, and for bleeding and adverse effects, with pacritinib dose reduction per labeling.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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