Drug interactions
Erythromycin + Talazoparib
Severity: Moderate
Erythromycin and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits P-gp and may raise talazoparib exposure. This could increase hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Erythromycin and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Talazoparib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by erythromycin reduces talazoparib efflux.
What to do
Prefer a non-P-gp-inhibiting antibiotic. If unavoidable, monitor blood counts and consider reducing the talazoparib dose per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Erythromycin with Talazoparib?
MediHelp rates the interaction as moderate. Erythromycin and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin inhibits P-gp and may raise talazoparib exposure. This could increase hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Erythromycin and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-P-gp-inhibiting antibiotic. If unavoidable, monitor blood counts and consider reducing the talazoparib dose per labeling.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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