Drug interactions
Erythromycin + Tepotinib
Severity: Moderate
Erythromycin and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may increase concentrations of P-gp substrates. Erythromycin is a P-gp substrate, so exposure could rise modestly, with greater risk of QT prolongation and GI effects.
What this interaction means in plain words
Erythromycin and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits intestinal P-glycoprotein efflux, increasing erythromycin absorption and exposure.
What to do
Monitor for erythromycin adverse effects, including QT prolongation, and consider an ECG in patients with risk factors. Consider an alternative antibiotic if the patient is at high arrhythmic risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Erythromycin with Tepotinib?
MediHelp rates the interaction as moderate. Erythromycin and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-glycoprotein and may increase concentrations of P-gp substrates. Erythromycin is a P-gp substrate, so exposure could rise modestly, with greater risk of QT prolongation and GI effects.
How serious is the interaction between Erythromycin and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erythromycin adverse effects, including QT prolongation, and consider an ECG in patients with risk factors. Consider an alternative antibiotic if the patient is at high arrhythmic risk.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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