Drug interactions
Erythromycin + Tucatinib
Severity: Moderate
Erythromycin and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and can increase concentrations of erythromycin, a CYP3A4 substrate. Higher erythromycin levels increase the risk of QT prolongation and gastrointestinal adverse effects.
What this interaction means in plain words
Erythromycin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin belongs to Anti Bacterial; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing erythromycin metabolism.
What to do
Consider an alternative antibiotic not dependent on CYP3A4. If used together, monitor ECG and for erythromycin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Erythromycin with Tucatinib?
MediHelp rates the interaction as moderate. Erythromycin and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and can increase concentrations of erythromycin, a CYP3A4 substrate. Higher erythromycin levels increase the risk of QT prolongation and gastrointestinal adverse effects.
How serious is the interaction between Erythromycin and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic not dependent on CYP3A4. If used together, monitor ECG and for erythromycin toxicity.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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