Drug interactions
Erythromycin base + Silodosin
Severity: Moderate
Erythromycin base and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and also affects P-gp. It can modestly raise silodosin levels, increasing the risk of orthostatic hypotension. The effect is smaller than with strong inhibitors.
What this interaction means in plain words
Erythromycin base and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Erythromycin inhibits CYP3A4 and P-gp, reducing silodosin metabolism and efflux.
What to do
Monitor for dizziness and orthostatic hypotension, especially at treatment start. Consider an alternative antibiotic such as azithromycin if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Erythromycin base with Silodosin?
MediHelp rates the interaction as moderate. Erythromycin base and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a moderate CYP3A4 inhibitor and also affects P-gp. It can modestly raise silodosin levels, increasing the risk of orthostatic hypotension. The effect is smaller than with strong inhibitors.
How serious is the interaction between Erythromycin base and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness and orthostatic hypotension, especially at treatment start. Consider an alternative antibiotic such as azithromycin if appropriate.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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