Drug interactions
Erythromycin lactobionate + Fluticasone-vilanterol
Severity: Moderate
Erythromycin lactobionate and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and can raise vilanterol and fluticasone furoate exposure, and it also prolongs the QT interval. This may increase beta-agonist cardiovascular effects and arrhythmia risk.
What this interaction means in plain words
Erythromycin lactobionate and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
CYP3A4 inhibition increasing vilanterol exposure, plus additive QT prolongation.
What to do
Monitor heart rate, ECG and potassium during IV therapy in patients with cardiac risk factors. Consider an alternative antibiotic if the risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin inhibits CYP3A4 and can raise vilanterol and fluticasone furoate exposure, and it also prolongs the QT interval. This may increase beta-agonist cardiovascular effects and arrhythmia risk.
How serious is the interaction between Erythromycin lactobionate and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium during IV therapy in patients with cardiac risk factors. Consider an alternative antibiotic if the risk is high.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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