Drug interactions
Erythromycin lactobionate + Secobarbital
Severity: Moderate
Erythromycin lactobionate and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital can induce CYP3A4 and reduce erythromycin concentrations. With intravenous erythromycin this may lead to reduced efficacy in serious infections.
What this interaction means in plain words
Erythromycin lactobionate and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Erythromycin lactobionate belongs to Anti Bacterial; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases erythromycin metabolism and lowers its plasma concentrations.
What to do
Monitor clinical response closely and choose an alternative antibiotic if the infection is not responding. Reassess therapy when secobarbital is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Secobarbital?
MediHelp rates the interaction as moderate. Erythromycin lactobionate and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital can induce CYP3A4 and reduce erythromycin concentrations. With intravenous erythromycin this may lead to reduced efficacy in serious infections.
How serious is the interaction between Erythromycin lactobionate and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response closely and choose an alternative antibiotic if the infection is not responding. Reassess therapy when secobarbital is started or stopped.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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