Drug interactions
Erythromycin lactobionate + Vinblastine
Severity: Major
Erythromycin lactobionate and Vinblastine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and P-gp and can substantially increase vinblastine exposure. Severe toxicity, including profound neutropenia and neurotoxicity, has been reported with macrolides and vinca alkaloids.
What this interaction means in plain words
Erythromycin lactobionate and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Erythromycin lactobionate belongs to Anti Bacterial; Vinblastine belongs to Oncology.
Why it happens
Erythromycin inhibits CYP3A4 metabolism and P-gp efflux of vinblastine.
What to do
Use a non-interacting antibiotic such as azithromycin where possible. If coadministered, monitor blood counts and neurologic function and reduce the vinblastine dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Vinblastine
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Erythromycin lactobionate with Vinblastine?
MediHelp rates the interaction as major. Erythromycin lactobionate and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Erythromycin inhibits CYP3A4 and P-gp and can substantially increase vinblastine exposure. Severe toxicity, including profound neutropenia and neurotoxicity, has been reported with macrolides and vinca alkaloids.
How serious is the interaction between Erythromycin lactobionate and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-interacting antibiotic such as azithromycin where possible. If coadministered, monitor blood counts and neurologic function and reduce the vinblastine dose as needed.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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