Drug interactions
Eslicarbazepine + Etonogestrel
Severity: Major
Eslicarbazepine and Etonogestrel: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine can lower progestin exposure and may cause contraceptive failure with etonogestrel implants or rings. Labeling for eslicarbazepine warns about reduced hormonal contraceptive effectiveness.
What this interaction means in plain words
Eslicarbazepine and Etonogestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eslicarbazepine belongs to Central Nervous System; Etonogestrel belongs to Endocrine.
Why it happens
CYP3A4 induction by eslicarbazepine accelerates etonogestrel metabolism.
What to do
Advise an additional or alternative non-hormonal method such as a copper IUD, or a levonorgestrel IUD, during therapy and for a period after stopping.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Etonogestrel
Frequently asked questions
Can I take Eslicarbazepine with Etonogestrel?
MediHelp rates the interaction as major. Eslicarbazepine and Etonogestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eslicarbazepine can lower progestin exposure and may cause contraceptive failure with etonogestrel implants or rings. Labeling for eslicarbazepine warns about reduced hormonal contraceptive effectiveness.
How serious is the interaction between Eslicarbazepine and Etonogestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional or alternative non-hormonal method such as a copper IUD, or a levonorgestrel IUD, during therapy and for a period after stopping.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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