Drug interactions
Eslicarbazepine + Fosaprepitant
Severity: Minor
Eslicarbazepine and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, which is a CYP3A4 substrate. Eslicarbazepine may lower aprepitant exposure and reduce antiemetic efficacy, though a single fosaprepitant dose is a short exposure.
What this interaction means in plain words
Eslicarbazepine and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eslicarbazepine belongs to Central Nervous System; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
CYP3A4 induction by eslicarbazepine increases aprepitant clearance.
What to do
Monitor for breakthrough nausea and vomiting and add rescue antiemetics as needed. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Eslicarbazepine with Fosaprepitant?
MediHelp rates the interaction as minor. Eslicarbazepine and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, which is a CYP3A4 substrate. Eslicarbazepine may lower aprepitant exposure and reduce antiemetic efficacy, though a single fosaprepitant dose is a short exposure.
How serious is the interaction between Eslicarbazepine and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting and add rescue antiemetics as needed. No routine dose change is needed.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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