Drug interactions
Eslicarbazepine + Ivacaftor
Severity: Moderate
Eslicarbazepine and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inducers greatly reduce ivacaftor exposure, risking loss of CFTR modulation. Eslicarbazepine is weaker but may still reduce levels.
What this interaction means in plain words
Eslicarbazepine and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Ivacaftor belongs to Miscellaneous.
Why it happens
CYP3A4 induction by eslicarbazepine increases ivacaftor metabolism.
What to do
Prefer a non-inducing antiseizure drug and monitor respiratory function and sweat chloride or clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Eslicarbazepine with Ivacaftor?
MediHelp rates the interaction as moderate. Eslicarbazepine and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP3A4 inducers greatly reduce ivacaftor exposure, risking loss of CFTR modulation. Eslicarbazepine is weaker but may still reduce levels.
How serious is the interaction between Eslicarbazepine and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure drug and monitor respiratory function and sweat chloride or clinical response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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