Drug interactions
Eslicarbazepine + Lovastatin
Severity: Moderate
Eslicarbazepine and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak inducer of CYP3A4 and may lower exposure to lovastatin, which is highly dependent on CYP3A4 metabolism. This could reduce the lipid-lowering effect of the statin.
What this interaction means in plain words
Eslicarbazepine and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Lovastatin belongs to Cardiovascular.
Why it happens
Induction of CYP3A4 by eslicarbazepine increases first-pass and systemic metabolism of lovastatin.
What to do
Check the lipid profile after starting or stopping eslicarbazepine. Increase the lovastatin dose if needed or switch to a statin not reliant on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Lovastatin?
MediHelp rates the interaction as moderate. Eslicarbazepine and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak inducer of CYP3A4 and may lower exposure to lovastatin, which is highly dependent on CYP3A4 metabolism. This could reduce the lipid-lowering effect of the statin.
How serious is the interaction between Eslicarbazepine and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the lipid profile after starting or stopping eslicarbazepine. Increase the lovastatin dose if needed or switch to a statin not reliant on CYP3A4.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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