Drug interactions
Eslicarbazepine + Nisoldipine
Severity: Moderate
Eslicarbazepine and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may markedly lower nisoldipine exposure, which is highly dependent on CYP3A4 first-pass metabolism. Blood pressure or angina control may worsen.
What this interaction means in plain words
Eslicarbazepine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Nisoldipine belongs to Cardiovascular.
Why it happens
CYP3A4 induction increases intestinal and hepatic metabolism of nisoldipine.
What to do
Monitor blood pressure and anginal symptoms and consider an alternative antihypertensive less dependent on CYP3A4.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Eslicarbazepine with Nisoldipine?
MediHelp rates the interaction as moderate. Eslicarbazepine and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine may markedly lower nisoldipine exposure, which is highly dependent on CYP3A4 first-pass metabolism. Blood pressure or angina control may worsen.
How serious is the interaction between Eslicarbazepine and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anginal symptoms and consider an alternative antihypertensive less dependent on CYP3A4.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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