Drug interactions
Eslicarbazepine + Simvastatin
Severity: Moderate
Eslicarbazepine and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak CYP3A4 inducer and has been shown to lower simvastatin exposure. Reduced statin effect may lead to less cholesterol lowering.
What this interaction means in plain words
Eslicarbazepine and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Simvastatin belongs to Cardiovascular.
Why it happens
Eslicarbazepine induces CYP3A4, increasing simvastatin metabolism.
What to do
Check lipid profile after starting eslicarbazepine and increase the simvastatin dose or switch statin if the lipid response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
- Darunavir + Simvastatin Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Simvastatin?
MediHelp rates the interaction as moderate. Eslicarbazepine and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak CYP3A4 inducer and has been shown to lower simvastatin exposure. Reduced statin effect may lead to less cholesterol lowering.
How serious is the interaction between Eslicarbazepine and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check lipid profile after starting eslicarbazepine and increase the simvastatin dose or switch statin if the lipid response is inadequate.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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