Drug interactions
Eslicarbazepine + Sonidegib
Severity: Major
Eslicarbazepine and Sonidegib: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sonidegib is a CYP3A4 substrate whose exposure falls with CYP3A inducers. Eslicarbazepine is a weaker inducer, but reduced efficacy in basal cell carcinoma is possible.
What this interaction means in plain words
Eslicarbazepine and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eslicarbazepine belongs to Central Nervous System; Sonidegib belongs to Oncology.
Why it happens
Eslicarbazepine induces CYP3A4, increasing sonidegib metabolism.
What to do
Avoid coadministration and choose a non-inducing antiseizure drug. If unavoidable, monitor tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Eslicarbazepine Amarox 200 mg tablets - SmPC sections 4.3/4.5 (class statement: medicinal products that are mainly metabolised through CYP3A4; "an increase in the dose of the medicinal products that are mainly metabolised through CYP3A4 may be required, when used concomitantly with Eslicarbazepine… — electronic medicines compendium (UK SmPC)
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Sonidegib
- Amiodarone + Sonidegib Major
- Apalutamide + Sonidegib Major
- Aprepitant + Sonidegib Major
- Armodafinil + Sonidegib Major
- Bosentan + Sonidegib Major
- Carbamazepine + Sonidegib Major
Frequently asked questions
Can I take Eslicarbazepine with Sonidegib?
MediHelp rates the interaction as major. Eslicarbazepine and Sonidegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sonidegib is a CYP3A4 substrate whose exposure falls with CYP3A inducers. Eslicarbazepine is a weaker inducer, but reduced efficacy in basal cell carcinoma is possible.
How serious is the interaction between Eslicarbazepine and Sonidegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and choose a non-inducing antiseizure drug. If unavoidable, monitor tumor response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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