Drug interactions
Eslicarbazepine + Tazemetostat
Severity: Major
Eslicarbazepine and Tazemetostat: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is cleared by CYP3A4, and inducers lower its plasma levels. Reduced exposure may impair antitumor activity.
What this interaction means in plain words
Eslicarbazepine and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eslicarbazepine belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Eslicarbazepine induces CYP3A4, increasing tazemetostat clearance.
What to do
Avoid combining with CYP3A inducers where possible and use a non-inducing antiseizure drug. If combined, monitor clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Eslicarbazepine Amarox 200 mg tablets - SmPC sections 4.3/4.5 (class statement: medicinal products that are mainly metabolised through CYP3A4; "an increase in the dose of the medicinal products that are mainly metabolised through CYP3A4 may be required, when used concomitantly with Eslicarbazepine… — electronic medicines compendium (UK SmPC)
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Eslicarbazepine with Tazemetostat?
MediHelp rates the interaction as major. Eslicarbazepine and Tazemetostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tazemetostat is cleared by CYP3A4, and inducers lower its plasma levels. Reduced exposure may impair antitumor activity.
How serious is the interaction between Eslicarbazepine and Tazemetostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with CYP3A inducers where possible and use a non-inducing antiseizure drug. If combined, monitor clinical response.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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