Drug interactions
Eslicarbazepine + Voriconazole
Severity: Moderate
Eslicarbazepine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may lower voriconazole concentrations through weak induction of CYP3A4, risking antifungal treatment failure. Its inhibition of CYP2C19 could also increase voriconazole levels, making the net effect unpredictable.
What this interaction means in plain words
Eslicarbazepine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Eslicarbazepine has mixed effects, inducing CYP3A4 and inhibiting CYP2C19, which both contribute to voriconazole clearance.
What to do
Monitor voriconazole trough concentrations and clinical response, and adjust the dose accordingly. Watch for loss of antifungal efficacy or voriconazole toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Voriconazole?
MediHelp rates the interaction as moderate. Eslicarbazepine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine may lower voriconazole concentrations through weak induction of CYP3A4, risking antifungal treatment failure. Its inhibition of CYP2C19 could also increase voriconazole levels, making the net effect unpredictable.
How serious is the interaction between Eslicarbazepine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor voriconazole trough concentrations and clinical response, and adjust the dose accordingly. Watch for loss of antifungal efficacy or voriconazole toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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