Drug interactions
Esmolol + Indacaterol-glycopyrronium
Severity: Moderate
Esmolol and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers antagonize the bronchodilator effect of indacaterol and may provoke bronchospasm in patients with airway disease. Esmolol is cardioselective and very short-acting, so the effect is usually brief and limited to the infusion period. Reduced response to the bronchodilator may still occur at higher doses.
What this interaction means in plain words
Esmolol and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta2 receptors; esmolol selectivity for beta1 diminishes at higher doses.
What to do
Use esmolol only when clearly needed and at the lowest effective dose, monitoring respiratory status and wheeze. Have a rescue bronchodilator available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Esmolol and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers antagonize the bronchodilator effect of indacaterol and may provoke bronchospasm in patients with airway disease. Esmolol is cardioselective and very short-acting, so the effect is usually brief and limited to the infusion period. Reduced response to the bronchodilator may still occur at higher doses.
How serious is the interaction between Esmolol and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use esmolol only when clearly needed and at the lowest effective dose, monitoring respiratory status and wheeze. Have a rescue bronchodilator available.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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