Drug interactions
Esmolol + Ivabradine
Severity: Moderate
Esmolol and Ivabradine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivabradine lowers heart rate by inhibiting the sinus node, and esmolol also slows heart rate. Combined use increases the risk of excessive bradycardia and conduction problems.
What this interaction means in plain words
Esmolol and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Ivabradine belongs to Cardiovascular.
Why it happens
Additive heart rate reduction via If channel inhibition and beta-1 blockade.
What to do
Monitor heart rate and ECG and reduce or stop one of the drugs if symptomatic bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Esmolol with Ivabradine?
MediHelp rates the interaction as moderate. Esmolol and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivabradine lowers heart rate by inhibiting the sinus node, and esmolol also slows heart rate. Combined use increases the risk of excessive bradycardia and conduction problems.
How serious is the interaction between Esmolol and Ivabradine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG and reduce or stop one of the drugs if symptomatic bradycardia develops.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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