Drug interactions
Esmolol + Labetalol
Severity: Moderate
Esmolol and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol blocks beta and alpha-1 receptors and esmolol adds beta-1 blockade, so additive bradycardia and hypotension can occur. This is mostly a duplication of therapy.
What this interaction means in plain words
Esmolol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive beta-adrenergic blockade, with alpha-1 mediated vasodilation from labetalol.
What to do
Avoid routine concurrent use and, if necessary, monitor blood pressure, heart rate and ECG continuously. Reduce or stop one agent if hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Esmolol with Labetalol?
MediHelp rates the interaction as moderate. Esmolol and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol blocks beta and alpha-1 receptors and esmolol adds beta-1 blockade, so additive bradycardia and hypotension can occur. This is mostly a duplication of therapy.
How serious is the interaction between Esmolol and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use and, if necessary, monitor blood pressure, heart rate and ECG continuously. Reduce or stop one agent if hypotension or bradycardia develops.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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