Drug interactions
Esmolol + Lasmiditan
Severity: Moderate
Esmolol and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan can lower heart rate, and with a beta-blocker the reduction was greater than with the beta-blocker alone in an interaction study. This could cause symptomatic bradycardia in susceptible patients.
What this interaction means in plain words
Esmolol and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive heart rate lowering from lasmiditan and beta-1 adrenergic blockade.
What to do
Monitor heart rate when lasmiditan is given to patients on esmolol or other beta-blockers. Avoid in patients with significant bradycardia or conduction block.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Esmolol with Lasmiditan?
MediHelp rates the interaction as moderate. Esmolol and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan can lower heart rate, and with a beta-blocker the reduction was greater than with the beta-blocker alone in an interaction study. This could cause symptomatic bradycardia in susceptible patients.
How serious is the interaction between Esmolol and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate when lasmiditan is given to patients on esmolol or other beta-blockers. Avoid in patients with significant bradycardia or conduction block.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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