Drug interactions
Esmolol + Losartan
Severity: Moderate
Esmolol and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol and losartan have additive blood pressure lowering effects and may cause hypotension. Losartan can raise potassium and is harmful in pregnancy.
What this interaction means in plain words
Esmolol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects of beta-blockade and angiotensin receptor blockade, with ARB-related potassium retention.
What to do
Monitor blood pressure, and serum potassium and renal function during continued losartan. Avoid losartan in pregnancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Esmolol with Losartan?
MediHelp rates the interaction as moderate. Esmolol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol and losartan have additive blood pressure lowering effects and may cause hypotension. Losartan can raise potassium and is harmful in pregnancy.
How serious is the interaction between Esmolol and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, and serum potassium and renal function during continued losartan. Avoid losartan in pregnancy.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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