Drug interactions
Esmolol + Mefloquine
Severity: Minor
Esmolol and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can slow cardiac conduction and cause bradycardia, and esmolol has similar negative chronotropic effects. Combination may cause additive bradycardia or conduction block, though esmolol's very short half-life limits the duration.
What this interaction means in plain words
Esmolol and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esmolol belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive effects on heart rate and AV conduction; esmolol is metabolized by blood esterases, so a metabolic interaction is not expected.
What to do
Monitor heart rate, blood pressure and ECG during esmolol infusion in patients taking mefloquine. Titrate esmolol cautiously.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Esmolol and Mefloquine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Mefloquine?
MediHelp rates the interaction as minor. Esmolol and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mefloquine can slow cardiac conduction and cause bradycardia, and esmolol has similar negative chronotropic effects. Combination may cause additive bradycardia or conduction block, though esmolol's very short half-life limits the duration.
How serious is the interaction between Esmolol and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG during esmolol infusion in patients taking mefloquine. Titrate esmolol cautiously.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
