Drug interactions
Esmolol + Tizanidine
Severity: Moderate
Esmolol and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol is a short-acting intravenous beta-blocker and tizanidine adds central hypotensive and bradycardic effects. Combined use can cause additive hypotension and bradycardia, mainly in monitored settings.
What this interaction means in plain words
Esmolol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive hypotensive and bradycardic effects from central alpha-2 agonism and beta-1 blockade.
What to do
Monitor blood pressure and heart rate continuously during esmolol infusion and titrate the dose cautiously in patients taking tizanidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Tizanidine?
MediHelp rates the interaction as moderate. Esmolol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol is a short-acting intravenous beta-blocker and tizanidine adds central hypotensive and bradycardic effects. Combined use can cause additive hypotension and bradycardia, mainly in monitored settings.
How serious is the interaction between Esmolol and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during esmolol infusion and titrate the dose cautiously in patients taking tizanidine.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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