Drug interactions
Esomeprazole + Lenacapavir
Severity: Minor
Esomeprazole and Lenacapavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A4 inhibitor and may increase exposure to CYP3A4 substrates. Esomeprazole relies mainly on CYP2C19, with CYP3A4 as a secondary route, so any increase is expected to be small and well tolerated.
What this interaction means in plain words
Esomeprazole and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, slightly reducing the secondary metabolic clearance of esomeprazole.
What to do
No dose adjustment is generally required; monitor for PPI adverse effects if high-dose esomeprazole is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Esomeprazole with Lenacapavir?
MediHelp rates the interaction as minor. Esomeprazole and Lenacapavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lenacapavir is a moderate CYP3A4 inhibitor and may increase exposure to CYP3A4 substrates. Esomeprazole relies mainly on CYP2C19, with CYP3A4 as a secondary route, so any increase is expected to be small and well tolerated.
How serious is the interaction between Esomeprazole and Lenacapavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor for PPI adverse effects if high-dose esomeprazole is used.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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