Drug interactions
Esomeprazole + Mesalamine
Severity: Moderate
Esomeprazole and Mesalamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some delayed-release mesalamine products release drug in a pH-dependent manner. Raising gastric pH with a proton pump inhibitor may cause premature release or altered release, which could reduce delivery to the colon and efficacy.
What this interaction means in plain words
Esomeprazole and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esomeprazole belongs to Gastrointestinal Tract; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH alters pH-dependent coating dissolution of certain mesalamine formulations.
What to do
Monitor for loss of disease control with pH-dependent mesalamine products. Consider a non-pH-dependent formulation or topical therapy if response falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Frequently asked questions
Can I take Esomeprazole with Mesalamine?
MediHelp rates the interaction as moderate. Esomeprazole and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Some delayed-release mesalamine products release drug in a pH-dependent manner. Raising gastric pH with a proton pump inhibitor may cause premature release or altered release, which could reduce delivery to the colon and efficacy.
How serious is the interaction between Esomeprazole and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of disease control with pH-dependent mesalamine products. Consider a non-pH-dependent formulation or topical therapy if response falls.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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