Drug interactions
Esomeprazole + Pexidartinib
Severity: Major
Esomeprazole and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole lowers pexidartinib absorption, which may reduce its efficacy in tenosynovial giant cell tumor.
What this interaction means in plain words
Esomeprazole and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Esomeprazole belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Higher gastric pH reduces the pH-dependent solubility and absorption of pexidartinib.
What to do
Avoid PPIs with pexidartinib. If an alternative is needed, take pexidartinib 2 hours before or after an antacid, or 2 hours before or 10 hours after an H2-receptor antagonist.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Esomeprazole with Pexidartinib?
MediHelp rates the interaction as major. Esomeprazole and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Esomeprazole lowers pexidartinib absorption, which may reduce its efficacy in tenosynovial giant cell tumor.
How serious is the interaction between Esomeprazole and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with pexidartinib. If an alternative is needed, take pexidartinib 2 hours before or after an antacid, or 2 hours before or 10 hours after an H2-receptor antagonist.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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