Drug interactions
Esomeprazole + Sparsentan
Severity: Moderate
Esomeprazole and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole may lower sparsentan exposure, potentially reducing its antiproteinuric benefit in IgA nephropathy. The clinical impact is mainly loss of efficacy.
What this interaction means in plain words
Esomeprazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esomeprazole belongs to Gastrointestinal Tract; Sparsentan belongs to Genitourinary.
Why it happens
Higher gastric pH from the PPI is thought to reduce the solubility and absorption of sparsentan.
What to do
Review the need for the PPI and use the lowest effective acid suppression if it is required. Monitor proteinuria and blood pressure response to sparsentan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Esomeprazole with Sparsentan?
MediHelp rates the interaction as moderate. Esomeprazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esomeprazole may lower sparsentan exposure, potentially reducing its antiproteinuric benefit in IgA nephropathy. The clinical impact is mainly loss of efficacy.
How serious is the interaction between Esomeprazole and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the need for the PPI and use the lowest effective acid suppression if it is required. Monitor proteinuria and blood pressure response to sparsentan.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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