Drug interactions
Esomeprazole + Tolbutamide
Severity: Minor
Esomeprazole and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A clinically important effect of esomeprazole on tolbutamide is not well documented. Tolbutamide is cleared mainly by CYP2C9, which esomeprazole does not meaningfully inhibit, and any pH-related absorption change is speculative.
What this interaction means in plain words
Esomeprazole and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Tolbutamide belongs to Endocrine.
Why it happens
Any effect is theoretical, possibly via altered gastric pH; no established mechanism.
What to do
No dose adjustment is required; monitor blood glucose as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Esomeprazole with Tolbutamide?
MediHelp rates the interaction as minor. Esomeprazole and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A clinically important effect of esomeprazole on tolbutamide is not well documented. Tolbutamide is cleared mainly by CYP2C9, which esomeprazole does not meaningfully inhibit, and any pH-related absorption change is speculative.
How serious is the interaction between Esomeprazole and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor blood glucose as usual.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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