Drug interactions
Esomeprazole + Voxelotor
Severity: Minor
Esomeprazole and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can raise exposure to drugs cleared by this pathway. Esomeprazole is cleared mainly by CYP2C19 with a smaller CYP3A4 contribution, and it has a wide therapeutic margin, so a clinically important rise in levels is unlikely.
What this interaction means in plain words
Esomeprazole and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Esomeprazole belongs to Gastrointestinal Tract; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor weakly inhibits CYP3A4, which handles a minor share of esomeprazole metabolism.
What to do
No dose change is normally needed; monitor for increased PPI adverse effects only if a patient has other factors reducing esomeprazole clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Esomeprazole with Voxelotor?
MediHelp rates the interaction as minor. Esomeprazole and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor inhibits CYP3A4 and can raise exposure to drugs cleared by this pathway. Esomeprazole is cleared mainly by CYP2C19 with a smaller CYP3A4 contribution, and it has a wide therapeutic margin, so a clinically important rise in levels is unlikely.
How serious is the interaction between Esomeprazole and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor for increased PPI adverse effects only if a patient has other factors reducing esomeprazole clearance.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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