Drug interactions
Estradiol + Levofloxacin
Severity: Minor
Estradiol and Levofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been proposed to lower oral hormone exposure by disrupting gut flora, but pharmacokinetic studies have generally not confirmed a meaningful effect. Any reduction in estradiol or contraceptive efficacy is likely to be very small.
What this interaction means in plain words
Estradiol and Levofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Theoretical reduction in enterohepatic recycling of estrogens through altered gut flora; not well established.
What to do
No routine change is needed. Advise patients to report breakthrough bleeding or loss of symptom control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Levofloxacin?
MediHelp rates the interaction as minor. Estradiol and Levofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been proposed to lower oral hormone exposure by disrupting gut flora, but pharmacokinetic studies have generally not confirmed a meaningful effect. Any reduction in estradiol or contraceptive efficacy is likely to be very small.
How serious is the interaction between Estradiol and Levofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise patients to report breakthrough bleeding or loss of symptom control.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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