Drug interactions
Estradiol + Linezolid
Severity: Minor
Estradiol and Linezolid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics that disrupt gut flora were thought to reduce enterohepatic recycling of estrogens, but linezolid has no convincing evidence of reducing hormonal contraceptive efficacy. Any clinical effect is likely to be negligible.
What this interaction means in plain words
Estradiol and Linezolid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Linezolid belongs to Anti Bacterial.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogens through altered intestinal flora.
What to do
No routine action is needed; counsel the patient to report breakthrough bleeding, and advise backup contraception if vomiting or diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Linezolid?
MediHelp rates the interaction as minor. Estradiol and Linezolid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics that disrupt gut flora were thought to reduce enterohepatic recycling of estrogens, but linezolid has no convincing evidence of reducing hormonal contraceptive efficacy. Any clinical effect is likely to be negligible.
How serious is the interaction between Estradiol and Linezolid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; counsel the patient to report breakthrough bleeding, and advise backup contraception if vomiting or diarrhea occurs.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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