Drug interactions
Estradiol + Mifepristone
Severity: Moderate
Estradiol and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may increase estradiol exposure through CYP3A4 inhibition. In addition, its antiprogestogen activity can reduce the endometrial protection provided by progestogens in women on hormone therapy.
What this interaction means in plain words
Estradiol and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Estradiol belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition plus progesterone receptor antagonism.
What to do
Monitor for estrogen excess effects and for abnormal uterine bleeding; reduce the estradiol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Mifepristone?
MediHelp rates the interaction as moderate. Estradiol and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may increase estradiol exposure through CYP3A4 inhibition. In addition, its antiprogestogen activity can reduce the endometrial protection provided by progestogens in women on hormone therapy.
How serious is the interaction between Estradiol and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess effects and for abnormal uterine bleeding; reduce the estradiol dose if needed.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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