Drug interactions
Estradiol + Neomycin
Severity: Minor
Estradiol and Neomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin alters gut flora that take part in enterohepatic recirculation of estrogens, which could theoretically reduce estradiol exposure. Evidence of reduced efficacy is weak, and contraceptive failure has been reported mainly as isolated cases with other antibiotics.
What this interaction means in plain words
Estradiol and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Neomycin belongs to Anti Bacterial.
Why it happens
Suppression of gut bacteria may reduce deconjugation and enterohepatic recycling of estrogens.
What to do
No routine change is needed. Advise patients using estradiol-based contraception of the small theoretical risk, and consider backup contraception during prolonged neomycin courses or if breakthrough bleeding occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Neomycin?
MediHelp rates the interaction as minor. Estradiol and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin alters gut flora that take part in enterohepatic recirculation of estrogens, which could theoretically reduce estradiol exposure. Evidence of reduced efficacy is weak, and contraceptive failure has been reported mainly as isolated cases with other antibiotics.
How serious is the interaction between Estradiol and Neomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise patients using estradiol-based contraception of the small theoretical risk, and consider backup contraception during prolonged neomycin courses or if breakthrough bleeding occurs.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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