Drug interactions
Estradiol + Nicardipine
Severity: Minor
Estradiol and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may inhibit P-glycoprotein and theoretically raise estradiol exposure slightly. Clinical consequences are unlikely to be significant.
What this interaction means in plain words
Estradiol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Nicardipine belongs to Cardiovascular.
Why it happens
Possible inhibition of P-glycoprotein efflux of estradiol by nicardipine.
What to do
No specific action is required. Monitor for estrogenic adverse effects such as breast tenderness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Nicardipine?
MediHelp rates the interaction as minor. Estradiol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may inhibit P-glycoprotein and theoretically raise estradiol exposure slightly. Clinical consequences are unlikely to be significant.
How serious is the interaction between Estradiol and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required. Monitor for estrogenic adverse effects such as breast tenderness.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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