Drug interactions
Estradiol + Oxytetracycline
Severity: Minor
Estradiol and Oxytetracycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracycline antibiotics were thought to lower estrogen levels by disrupting gut flora, but supporting evidence is poor. Meaningful loss of effect is unlikely.
What this interaction means in plain words
Estradiol and Oxytetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Oxytetracycline belongs to Anti Bacterial.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogen via altered gut flora.
What to do
No action is generally needed; advise reporting breakthrough bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Oxytetracycline
- Isotretinoin + Oxytetracycline Contraindicated
- Aluminum hydroxide + Oxytetracycline Moderate
- Ampicillin-sulbactam + Oxytetracycline Moderate
- Ampicillin + Oxytetracycline Moderate
- Atracurium + Oxytetracycline Moderate
- Bismuth subsalicylate + Oxytetracycline Moderate
Frequently asked questions
Can I take Estradiol with Oxytetracycline?
MediHelp rates the interaction as minor. Estradiol and Oxytetracycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracycline antibiotics were thought to lower estrogen levels by disrupting gut flora, but supporting evidence is poor. Meaningful loss of effect is unlikely.
How serious is the interaction between Estradiol and Oxytetracycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed; advise reporting breakthrough bleeding.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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