Drug interactions
Estradiol + Vancomycin
Severity: Minor
Estradiol and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vancomycin is hypothetically able to disrupt gut bacteria that deconjugate estrogens for enterohepatic recycling, which could slightly lower estradiol levels. Convincing evidence of reduced hormonal efficacy or contraceptive failure with vancomycin is lacking.
What this interaction means in plain words
Estradiol and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Vancomycin belongs to Anti Bacterial.
Why it happens
Possible reduced enterohepatic recirculation of estrogen due to altered gut flora; not firmly established.
What to do
No routine action is needed. Advise patients to report breakthrough bleeding or return of menopausal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Estradiol with Vancomycin?
MediHelp rates the interaction as minor. Estradiol and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vancomycin is hypothetically able to disrupt gut bacteria that deconjugate estrogens for enterohepatic recycling, which could slightly lower estradiol levels. Convincing evidence of reduced hormonal efficacy or contraceptive failure with vancomycin is lacking.
How serious is the interaction between Estradiol and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Advise patients to report breakthrough bleeding or return of menopausal symptoms.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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